The main reason to choose one over the other is the position of the inlet and outlet pipes. If you for instance need the outlet to come out directly up over the rad support or at a 90 vertical from the core then vertical would work. In most cases horizontal works just fine.
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2004 Nissan Titan SE KC 4X2: AEM Brute Force Intake, NISMO Exhaust, NISMO Shock Kit, PRG Upper Control Arms, PRG Sway Bar Endlinks, PRG LCA Spacers, Eagle Alloy 17x8, Nitto Terra Grappler 295/75/17, Alpine iXA-W404, Apline Power Pack, Apline KCE-400BT, Alpine Imprint, Alpine Type-R Door Speakers, US Amps USA-400, JBL GTO0804
2004 Nissan 350Z: Turbonetics Stage 1 Turbo System, Apexi WS2, HKS LS+ Coilovers with Swift Springs, Hotchkis Sway Bars, NISMO LSD, NISMO Diff Cover, ACT Clutch, JWT Flywheel, GSpec Short Shifter, Hawk HPS pads, Blitz Upper Raditor Hose, Motordyne 5/16" Plenum Spacer, Volk LE37T 19x8.5 and 19x10.5, Blitz FATT DCIII
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